*Very* different from previous comics. For one, this is the first that takes place on Earth instead of whatever ponified Hollywood Equestria the others exist in.
And two, technically has no real ponies. Go figure. Does that make this a misnomer? Ah well.
Could the Thing mimic a Pony? Well, it doesn't have to worry about being a perfect copy, so I don't see why not. It certainly seemed fine with guesswork and improvisation in dispatching Base 31.
If you've not seen the 1982 "The Thing", you need to. Do it now. Go!
And no, I will never be addressing the 2011 version. That's all there is to say about the matter.